Radically
reversing
aging

We define the core biological mechanisms of aging.
We stop age-related diseases and pathological processes at the cellular level, before they start.
We help people live better and live longer
We work at the molecular level to slow down and reverse aging-related cellular dysfunction
Our multi-factor approach focuses on radical interventions in complex with drugs and lifestyle to stop deterioration across the human body
Personalized Centaura complex approach
Health data acquisition
Multi-omics data
Laboratory tests &
diagnostic procedures
Medical records
Biological age assessment
Age profile based on functional performance of organ systems
Rejuvenation program development: Cell functionality optimization &
health recommendations
Molecular medicine interventions
  • Gene editing
  • Epigenetic modification
  • Gene & protein expression optimization
  • MicroRNA therapy
  • Advanced stem cell therapy
  • Artificial tissue
  • Organ rejuvenation
  • Closed-loop implant
Lifestyle & medication
  • Lifestyle guidelines
  • Geroprotector
    cocktail
Continuous monitoring
Our
tools and methods
will create a future where people will have
the wisdom of experience
and
the health of youth
Aging correlates to biological age (BA)
BA measures the real functional state of an individual’s organs and tissues, and is an expression of heredity, clinical record, and lifestyle. By improving the functional capacity of the organs and tissues at the cellular level, we push back BA, restoring function and health in a lasting way.
Biological age Chronological age 35
35 Chronological age Biological age
A lower BA corresponds
to a longer lifespan
and healthspan — that period of life when a person is disease-free and fully functional both physically and cognitively
Lifespan
120+ 75
Healthspan
Source: World Health Organisation statistics
SAB
To realize these aims, we collaborate with leading scientists and universities around the world and perform in-house research at our laboratories in Switzerland
Prof. Brian Kennedy

Distinguished Professor of the Department
of Biochemistry and Physiology of Yong
Loo Lin School of Medicine, Singapore

Director of National University Health
System Centre for Healthy Ageing, Singapore

Dr. Joao Pedro De Magalhaes, PhD

Associate Professor at the University
of Liverpool, England

Prof. Vadim Gladyshev

Professor of Medicine
at Harvard Medical School

Director of Redox Medicine
at Brigham and Women’s Hospital

Dr. Vera Gorbunova

Professor of Biology
at the University of Rochester

Co-director of the Rochester
Aging Research Center

Dr. Andrei Seluanov

Professor of Biology
at the University of Rochester

Prof. Jerry William Shay

Professor and Vice Chairman
at the Department
of Cell Biology
and Southland Foundation

Distinguished Chair in Geriatric
Research
at The University of Texas
Southwestern Medical Center

Associate Director at the The University
of Texas
Southwestern Simmons
Comprehensive Cancer Center

Our current research projects include
Multi-omics
We aim to map individual aging profiles, represented as trajectories of functional decline in each organ system. To achieve this, we will combine multi-omic profiles with medical records. By applying methods from systems biology, machine learning analyses, and artificial intelligence algorithms, we will identify the primary drivers of degeneration in each organ. This approach will allow us to generate novel predictors that can be used to guide clinical intervention.
MicroRNA delivery
We are investigating whether delivering miRNA into aging cells can modulate gene expression and rejuvenate cells. Our research is focused on identifying miRNA that control the processes of aging.
Gene therapy
Existing gene therapy vehicles are limited in their ability to deliver large genetic loads. This poses a major challenge to treating and reversing aging, due to the complexity of aging-related diseases and the large number of genes that may need to be modulated to fight aging. Centaura is investing in cutting-edge technologies to efficiently and stably deliver large-scale gene therapy that will retune the expression of multiple genes. This will enable scientists to rapidly and precisely test anti-aging gene therapies in human cells and animal models.
Mobile Elements
Transposable elements are genomic "parasites" that constitute approximately 30% of mammalian genomes. These elements are repressed in younger cells, but become active as cells age. Their activation promotes aging and aging‑related inflammation.
At Centaura, we are investigating ways to deactivate transposable elements and prevent cell aging.
Define
the future with us
We are looking for independent, highly motivated recent PhD graduates
and postdoctoral researchers
with a strong background in:
  • Genetics
  • Epigenetics
  • Molecular biology
  • Cell biology
  • Regenerative medicine
  • Neuroscience
  • Immunology
  • Systems biology
  • Bioinformatics
  • Machine learning
  • Biochemistry
  • Biomaterials
  • Synthetic biology
  • Biostatistics
  • Clinical practice